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Weight Gain

Fluoxetine does not prevent weight gain in olanzapine-treated patients

Published in Obesity and Diabetes Week, May 19th, 2003

Results from a double-blind, randomized trial indicate that fluoxetine does not prevent weight gain in schizophrenic patients treated with olanzapine.

"Significant weight gain is a side effect associated with olanzapine treatment in some patients. We investigated the efficacy of high-dose fluoxetine as a weight-reducing agent for patients who develop early weight gain with olanzapine treatment," scientists in the United States report.

"Patients that gained {{>=}}3% of their baseline weight in the initial eight weeks of olanzapine treatment (n=31) were randomized to double-blind treatment with placebo or fluoxetine (60 mg/day)," stated Juan R....

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