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Obesity Therapy

Acarviosine-simmondsin reduces food intake and hyperglycemia

Published in Obesity and Diabetes Week, June 2nd, 2003

Acarviosine-simmondsin, a novel compound obtained from acarviosine-glucose and simmondsin by Thermus maltogenic amylase, reduced food intake and hyperglycemia.

According to a study from South Korea, "Simmondsin was modified with acarviosine-glucose using the transglycosylation activity of Thermus maltogenic amylase to synthesize a novel compound with both anti-obesity and hypoglycemic activity. The LC/MS and C-13 NMR analyses confirmed that the structure of the major transglycosylation product was acarviosine-simmondsin (Acv-simmondsin), in which acarviosine was attached to the glucose moiety of simmondsin by an alpha-(1,6)-glycosidic linkage."

"It...

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