Diabetes Pathogenesis
Girl develops hyperinsulinism and overgrowth without obesity
Published in Obesity and Diabetes Week, June 2nd, 2003
According to a study from Australia, "We report a five-year-old girl with postnatal overgrowth (height velocity >97th centile), hyperinsulinemia, and increased insulin-like growth factor 1 for age, without evidence of bioactive or immunoreactive growth hormone excess or pituitary abnormality."
"Although her overgrowth may be a result of hyperinsulinism, her serum contains a factor (neither insulin nor IGF-1) which is able to stimulate the proliferation of lymphocyte precursors, and this could also account for the overgrowth," reported S. Srinivasan...
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