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Type 2 Diabetes Therapy

Soy isoflavones exert antidiabetic and hypolipidemic effects through PPAR

Published in Obesity and Diabetes Week, July 7th, 2003

Soy isoflavones exert antidiabetic and hypolipidemic effects through the PPAR pathways in obese rats and murine cells.

"The hypocholesterolemic and anti-atherosclerotic mechanism by which soy may exert a beneficial effect remains unclear. Peroxisome-proliferator activated receptors PPAR) are promiscuous nuclear receptors that regulate the transcription of genes involved in lipid and glucose homeostasis and lipid metabolism within the cell. We hypothesize that the isoflavones improve lipid and glucose metabolism by acting as an antidiabetic PPAR agonist," scientists writing in the Journal of Nutrition report.

"Male and female obese Zucker rats...

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