Late-onset obesity develops in mice transgenic for the human renin gene

According to recent research from Japan, "We previously generated a strain of transgenic mice carrying the human renin gene, hRN8-12, in the background of C57BL/6j. In this study, we discovered that hRN8-12 male mice, but not females, developed obesity starting at 15 weeks of age."

"The body weight of 60-week-old male transgenic mice was two times higher than that of age-matched wild-type mice," reported S. Uehara and colleagues at the University of Tsukuba. "Interestingly, male mice heterozygous for the human renin gene showed moderate weight gain compared with transgenic and...

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