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Pathogenesis

Insulin-secreting beta-cell dysfunction induced by human lipoproteins

Published in Obesity and Diabetes Week, July 21st, 2003

Insulin-secreting beta-cell dysfunction is induced by human lipoproteins.

According to recent research published in the Journal of Biological Chemistry, "Diabetes is associated with significant changes in plasma concentrations of lipoproteins. We tested the hypothesis that lipoproteins modulate the function and survival of insulin-secreting cells."

"We first detected the presence of several receptors that participate in the binding and processing of plasma lipoproteins and confirmed the internalization of fluorescent low density lipoprotein (LDL) and high density lipoprotein (HDL) particles in insulin-secreting beta-cells," reported...

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