Receptor Studies

Adiponectin involved in antidiabetic activities

Published in Obesity and Diabetes Week, July 21st, 2003

by Maria G. Essig, MS, ELS, senior medical writer - The two adiponectin receptors, AdipoR1 and AdipoR2, promote the actions of adenosine monophosphate (AMP) kinase and peroxisome proliferator activated receptor alpha (PPAR-alpha) ligands, according to a report in the journal Nature.

"Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine," stated Toshimasa Yamauchi and collaborators at the University of Tokyo, Kyorin Pharmaceutical, and Keio University in Japan. "Levels of adiponectin in the blood are decreased under conditions of obesity,...

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Source: Obesity and Diabetes Week (2003-07-21)

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