Diabetes Risk Factor

Cadmium induces impaired glucose tolerance by down-regulating GLUT4

Published in Obesity and Diabetes Week, July 21st, 2003

Cadmium induces impaired glucose tolerance in rats by down-regulating GLUT4 expression in adipocytes.

According to a study from South Korea and the United States, "Cadmium (Cd) has been known to cause hyperglycemia with diabetes-related complications in experimental animals; however, the molecular basis underlying this Cd-induced hyperglycemia is not known. Here, we report the novel finding that the impaired glucose tolerance (IGT) in rats induced by CdCl2 is accompanied by a drastic (by as much as 90%) and dose-dependent reduction in GLUT4 protein and GLUT4 mRNA levels in adipocytes."

"The effect was specific to GLUT4; neither GLUT1 nor...

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Source: Obesity and Diabetes Week (2003-07-21)

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