Obesity Genomics and Genetics

Allele linked to diabetes in Pima Indians mediated by obesity

Published in Obesity and Diabetes Week, July 28th, 2003

Pima Indians who are homozygous for the Asp1057 allele in insulin receptor substrate have a greater risk of type 2 diabetes that may be affected by interaction of the polymorphism with obesity.

According to a study from the United States, "Insulin receptor substrate (IRS)-2 plays an important role in insulin signaling and its disruption results in diabetes in mice. In humans, the IRS-2 Gly1057Asp substitution was associated with lower risk of type 2 diabetes in lean individuals, but with a higher risk in obese individuals. To clarify the role of IRS-2 on the development of type 2 diabetes and obesity in Pima Indians, and particularly to investigate whether the effects...

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Source: Obesity and Diabetes Week (2003-07-28)

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