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Diabetes Genomics and Genetics

No link found between type 2 diabetes mellitus and HFE gene mutations

Published in Obesity and Diabetes Week, August 25th, 2003

No significant association was found between type 2 diabetes mellitus and the HFE gene mutations leading to hereditary hemochromatosis.

According to a study from England, "Diabetes mellitus is a recognized consequence of hereditary hemochromatosis. Whether the common HFE mutations, that associate with this condition and pre-dispose to increases in serum iron indices, are over-represented in diabetic populations remains controversial."

"We present data from the largest case-control study of the C282Y and H63D HFE allele frequencies in typical type 2 diabetes mellitus, as defined by an age of onset greater than 30 years and no requirement for insulin...

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