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Diabetic Nephrology

Apoptosis of tubular epithelial cells occurs in diabetic glycogen nephrosis

Published in Obesity and Diabetes Week, September 15th, 2003

Apoptosis of tubular epithelial cells occurs in diabetic glycogen nephrosis.

According to a study from Canada, "The important problem of the fate of glycogen-accumulating clear cells in glycogen nephrosis is still unsettled. In this study, we examine whether apoptosis plays a relevant role in the development of diabetic glycogen nephrosis and explore the involvement of the Fas/Fas-L system and the activation of the caspase cascade."

"Diabetes was induced in rats by streptozotocin injection," stated Saoussen Bamri-Ezzine and colleagues at the University of Montreal. "Glycogen-accumulating clear cells were identified in renal tissues of hyperglycemic...

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