Eating Disorders

Slimming drug explained

Published in Obesity and Diabetes Week, September 15th, 2003

Scientists are beginning to understand how OEA, a naturally occurring compound that stops mice from overeating, has its effects. Research reveals that the molecule binds to a receptor known as PPAR-alpha. Molecules designed to target this receptor may prove to be effective treatments for eating disorders.

OEA, or oleylethanolamide, is known to regulate feelings of "fullness" and body weight. Daniele Piomelli and colleagues writing in the September 4, 2003, issue of Nature showed that the molecule binds to the nuclear protein, mimicking the action of other synthetic PPAR-alpha-stimulating drugs. It reduces weight gain in normal mice, but fails to do so in mice...

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Source: Obesity and Diabetes Week (2003-09-15)

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