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Leptin Studies

Leptin peptide is potent inhibitor of leptin receptor function

Published in Obesity and Diabetes Week, September 29th, 2003

A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells.

According to recent research from the United States, "In this article we show that rabbit endometrial cells express leptin receptor and that human leptin triggers phosphorylation of signal transducer and activator of transcription 3 and up-regulates the expression of interieukin-1 receptor type I as was previously found in human endometrial cells."

"Interestingly, leptin also upregulates the secretion of leukemia inhibitory factor and expression of its receptor by rabbit endometrial cells," reported Ruben Rene Gonzalez...

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