Published in Obesity and Diabetes Week, October 13th, 2003
According to a study from the United States, "a variety of toxic insults can result in endoplasmic reticulum (ER)-stress that ultimately leads to apoptosis. Beta-cells have a highly developed ER due to a great commitment to insulin production. The present study was carried out to determine the role of ER-stress in isolated human pancreatic islet apoptosis, and the potential protective effects of Bcl-2."
"Isolated human islets were infected with an adenoviral vector encoding Bcl-2 and then exposed to brefeldin-A, tunicamycin, A23187, and pro-inflammatory cytokines. Activation of...
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