Leptin Studies

Cerebral endothelial barrier not altered in diet-induced obesity

Published in Obesity and Diabetes Week, October 13th, 2003

The cerebral endothelial barrier is not altered in diet-induced obesity.

According to a study from Germany, "Leptin, a potent anorectic, 16-kDa, adipose tissue-derived protein, predominantly acts in hypothalamic nuclei, signaling obesity and modulating ingestive behavior. To reach this brain area, leptin, probably has to cross the blood-brain barrier (BBB). In some cases of obesity, enhanced leptin levels in the blood do not result in anorectic effects, probably due to an altered leptin transport across the BBB."

"Therefore, we investigated the BBB in lean and diet-induced obese Lewis rats," said Heike Nave and colleagues at Hannover Medical School....

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Source: Obesity and Diabetes Week (2003-10-13)

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