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Diabetes Genomics and Genetics

Zinc-finger gene ZNF236 unlikely to promote diabetic nephropathy

Published in Obesity and Diabetes Week, October 20th, 2003

The Kruppel-like zinc-finger gene ZNF236 has been excluded as a susceptibility gene for diabetic nephropathy.

"Diabetic nephropathy (DN) is the most common cause of renal failure in the western hemisphere. Epidemiological studies have suggested a genetic susceptibility for DN," scientists in Germany report.

"Linkage analysis showed evidence for a locus on chromosome 18q22.3-q23 in Turkish families," stated Niels Halama and colleagues at the University of Heidelberg. "We report the construction of a transcript map of the target region on chromosome 18q22.3-q23 and analysis of the candidate gene ZNF236. By using recent publications, human genome...

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