Cardiology
Carboxyl terminus of beta(2)AR needed for cardiac myocyte signaling
Published in Obesity and Diabetes Week, November 10th, 2003
According to recent research from California, "beta(1)- and beta(2)-adrenergic receptors (AR) regulate cardiac myocyte function through distinct signaling pathways."
"In addition to regulating cardiac rate and contractility, beta(1)AR and beta(2)AR may play different roles in the pathogenesis of heart failure," noted Y. Xiang and coauthors at Stanford University. "Studies on neonatal cardiac myocytes from beta(1)AR and beta(2)AR knockout mice suggest that subtype-specific signaling is determined by subtype-specific membrane targeting and trafficking."
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