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Leptin Studies

Leptin reduces food intake in cold-acclimated rats

Published in Obesity and Diabetes Week, November 10th, 2003

Leptin administration to cold-acclimated rats reduced both food intake and brown adipose tissue thermogenesis.

According to a study from Spain, "Acute (24-hour) and chronic (three-week) cold-exposure causes an increase in energy utilization to maintain body temperature. As a result, there is a decrease in body fat, a reduced plasma leptin concentration, and a concomitant hyperphagia."

"When cold-acclimated rats were subjected to a chronic administration of leptin, a reduction in food intake was observed," reported Maria Abelenda and colleagues at Complutense University in Madrid. "This finding demonstrates that leptin can display its satiating role...

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