Obesity & Diabetes Week
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Cholesterol Transporter
Caveolin-1 may move through lipid bilayer instead of endocytic membrane budding
November 24th, 2003
Caveolin-1 appears to move through the lipid bilayer rather than go through endocytic membrane budding. "Caveolin-1, a major protein of cell surface invaginations called caveolae, is currently believed to cycle between the plasma membrane and intracellular compartments via the endocytotic pathway, at least for part of its itinerary," investigators in Germany report. "We studied the distribution of caveolin-1 in cell membranes, using ultrathin cryosections and freeze-fracture immunolabeling, and found this protein not only in the cytoplasmic leaflet of the plasma membrane, but also in the exoplasmic leaflet of all intracellular membranes. This...
Source: Obesity & Diabetes Week (2003-11-24)
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