Obesity & Diabetes Week
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Diabetes Pathogenesis
Mechanisms altered in insulin resistance reviewed
November 24th, 2003
A scientist has published a review on the mechanisms altered in insulin resistance in a recent issue of the journal MS - Medecine Sciences. "Insulin has a major anabolic function leading to storage of lipidic and glucidic substrates. All its effects result from insulin binding to a specific membrane receptor, which is expressed at a high level on the three insulin target tissues: liver, adipose tissue, and muscles. The insulin receptor exhibits a tyrosine-kinase activity that leads, first, to receptor auto phosphorylation and then to tyrosine phosphorylation of substrates proteins, IRS proteins in priority. This leads to the formation of macromolecular complexes...
Source: Obesity & Diabetes Week (2003-11-24)
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