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Obesity Genomics and Genetics
Mitochondrial DNA 15497G/A polymorphism linked to obesity in Japanese
November 24th, 2003
The mitochondrial DNA 15497G/A polymorphism is associated with obesity in a middle-aged and elderly Japanese population. "Although polymorphism of the mitochondrial DNA 15497guanine/adenine (Mt15497G-->A) leads to the Gly251Ser amino acid replacement on human cytochrome b, it is unknown whether functional alteration of the mitochondrion is induced by the Gly251Ser replacement. To see if an association exists between the Mt15497G-->A polymorphism and obesity, we examined differences in body size, body composition, and regional body fat distribution between the two genotypes in middle-aged and elderly Japanese individuals (825 women and 906 men)," scientists in...
Source: Obesity & Diabetes Week (2003-11-24)
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