Insulin Resistance
PPAR agonist improves insulin resistance of adipose tissue in mice
Published in Obesity and Diabetes Week, November 24th, 2003
According to recent research from Japan, "Thiazolidinediones (TZDs), agonists for PPARs, have been shown to block the inhibitory effects of TNF-alpha on insulin action using cultured cells. In order to clarify the in vivo effects of TZDs on the inhibition of insulin sensitivity by TNF-alpha on insulin action in muscles and adipose tissues was assessed in the TNF-alpha-overexpression mice model using transplantation of cells secreting the TNF-alpha protein."
"After the pioglitazone treatment for four weeks, glucose uptake, insulin-induced IRS-1 phosphorylation, and...
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