Obesity & Diabetes Week
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Insulin Resistance
PPAR agonist improves insulin resistance of adipose tissue in mice
November 24th, 2003
A PPAR agonist improves TNF-alpha-induced insulin resistance of adipose tissue in mice. According to recent research from Japan, "Thiazolidinediones (TZDs), agonists for PPARs, have been shown to block the inhibitory effects of TNF-alpha on insulin action using cultured cells. In order to clarify the in vivo effects of TZDs on the inhibition of insulin sensitivity by TNF-alpha on insulin action in muscles and adipose tissues was assessed in the TNF-alpha-overexpression mice model using transplantation of cells secreting the TNF-alpha protein." "After the pioglitazone treatment for four weeks, glucose uptake, insulin-induced IRS-1 phosphorylation, and...
Source: Obesity & Diabetes Week (2003-11-24)
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