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Diabetes Pathogenesis
Syntaxin 4 regulates insulin secretion in pancreatic beta HC-9 cells
November 24th, 2003
Syntaxin 4 and Syntaxin 4 interacting protein regulate insulin secretion in the pancreatic beta HC-9 cell. According to recent research published in the Journal of Biological Chemistry, "Although syntaxin 1 is generally thought to function as the primary target-N-ethylmaleimide-sensitive factor attachment protein receptor required for pancreatic beta cell insulin secretion, we have observed that overexpression of a dominant-interfering syntaxin 4 mutant (syntaxin 4/DeltaTM) attenuated glucose-stimulated insulin secretion in beta HC-9 cells. Furthermore, these cells express the selective syntaxin 4-binding protein Synip (syntaxin 4 interacting protein), and Synip...
Source: Obesity & Diabetes Week (2003-11-24)
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