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Leptin Studies

Leptin and insulin modulate nutrient partitioning and weight loss

Published in Obesity and Diabetes Week, December 1st, 2003

Leptin and insulin modulate nutrient partitioning and weight loss in ob/ob mice through regulation of long-chain fatty acid uptake by adipocytes.

According to recent research from the United States, "Leptin treatment of ob/ob mice leads to weight loss appreciably greater than that in pair-fed mice. To test whether this 'extra' weight loss is mediated by leptin-induced alterations in nutrient partitioning, the effects in ob/ob mice of subcutaneous leptin infusion (500 ng/h for {{<=}}21 days) on adipocyte fatty acid uptake and transporter gene expression were examined."

"Mice were initially hyperinsulinemic (5.25±1.57 nmol/L)," said Xinqing...

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