Diabetic Nephropathy
Beta defensin-1 mRNA elevated in diabetic kidneys of GK rats
Published in Obesity and Diabetes Week, December 8th, 2003
According to published research from England, "We previously described the isolation of CDK4, representing the 3'end of an unknown mRNA, using differential display. To determine the identity of the CDK4 gene, full-length CDK4 cDNA clones were isolated from a diabetic kidney cDNA library. DNA sequencing revealed that CDK4 represents the rat beta defensin-1 gene (rBD-1)."
"rBD-1 mRNA was detected in rat kidney, heart, lung, and skeletal muscle using RT-PCR," reported Rachel A. Page and Afshan N. Malik at Kings College London. "Using Northern blot analysis, elevated levels of...
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