Diabetes Therapy

Novel insulin analog with enhanced beta-cell protection described

Published in Obesity and Diabetes Week, December 15th, 2003

Researchers have developed a novel insulin analog with enhanced beta-cell protective action.

According to a study from Germany, "Insulin receptor substrate (IRS)-2 has been implicated in the promotion of beta-cell survival. Here we tested the hypothesis that the novel analog [LysB3, GluB29] insulin (insulin glulisine, IG) might mediate an enhanced beta-cell protective effect due to its unique property of preferential IRS-2 phosphorylation. We assessed IRS activation by IG and its anti-apoptotic activity against cytokines or palmitic acid in comparison to insulin, insulin analogs, and insulin-like growth factor (IGF)-1 using INS-1 cells."

"IG induced...

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Source: Obesity and Diabetes Week (2003-12-15)

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