Published in Obesity and Diabetes Week, January 5th, 2004
Scientists have long known that hunger causes increases in some brain chemicals while lowering others. However, the root cause of hunger's effects - the initial chemical trigger of appetite - has been elusive.
In experiments with mice, the Johns Hopkins researchers showed that appetite is immediately and directly tied to amounts of a chemical called malonyl-CoA. In hungry mice, malonyl-CoA was almost undetectable in the brain. Once fasting mice were given food, however, amounts...
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