Diabetic Nephropathy

12-Lipoxygenase plays role in experimental diabetic nephropathy

Published in Obesity and Diabetes Week, January 12th, 2004

12-Lipoxygenase plays a role in the stimulation of p38 mitogen-activated protein kinase and collagen alpha 5(IV) in experimental diabetic nephropathy

According to published research from the United States, "The 12-lipoxygenase (12-LO) pathway of arachidonic acid metabolism is implicated in extracellular matrix (ECM) synthesis, but its role in podocytes has not been studied. This study tested whether 12-LO induction by diabetes or by high glucose (HG) in cultured podocytes alters glomerular basement membrane by activating signal transduction pathways culminating in ECM synthesis."

"Sprague-Dawley rats received an injection of diluent (control [C]) or...

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Source: Obesity and Diabetes Week (2004-01-12)

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