Pancreatic Islets
Interactions of polymeric sulfonylurea with pancreatic islets examined
Published in Obesity and Diabetes Week, January 19th, 2004
"Using a polymeric sulfonylurea (PSU) designed from glibenclamide, we examined the interactions of sulfonylurea with pancreatic islets rather than genetically remodeled beta-cell lines to clarify the biological roles of ATP-sensitive K+ (K-ATP) channels to which sulfonylurea binds. PSU enhanced insulin secretion from the islets with 10 nM (SU equivalent) treatment, especially at low glucose concentration, but its activity was inhibited by 100 micromolar diazoxide.
"Confocal microscopy visualized PSU interactions with the islet and...
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