Diabetes Pathogenesis

Beta cell death triggers priming of self-reactive T cells by dendritic cells

Published in Obesity and Diabetes Week, January 19th, 2004

Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type 1 diabetes model.

"The prelude to type 1 diabetes is leukocyte infiltration into the pancreatic islets, or insulitis. This process begins in pancreatic lymph nodes when T lymphocytes reactive to islet beta cells encounter antigen-presenting cells (APCs) displaying peptides derived from beta cell proteins," researchers in the United States report.

"We show here that a ripple of physiological beta cell death, which occurs at two weeks of age in all mouse strains, precipitates the arrival of such APCs, and that the relevant APC is a dendritic cell of...

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Source: Obesity and Diabetes Week (2004-01-19)

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