Obesity Genomics and Genetics
Allelic variants of SLC6A14 linked to obesity
Published in Obesity and Diabetes Week, February 2nd, 2004
According to research from Finland, the United States, and Sweden, "In our previous genome-wide scan of Finnish nuclear families, obesity was linked to chromosome Xq24. Here we analyzed this 15-Mb region by genotyping 9 microsatellite markers and 36 single nucleotide polymorphisms (SNPs) for 11 positional and functional candidate genes in an extended sample of 218 obese Finnish sibling pairs (sibpairs) (BMI>30 kg/m2).
"Evidence of linkage emerged mainly from the obese male sibpairs, suggesting a gender-specific effect for the underlying gene. By constructing haplotypes among the...
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