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Diabetes Pathogenesis

Long-term high-fat/low-carbohydrate diet causes diabetes in rats

Published in Obesity and Diabetes Week, February 2nd, 2004

Diabetes developed in Wistar rats kept on a high-fat/low-carbohydrate diet for long periods.

According to published research from Japan, "The present study was performed to determine the effect of long-term feeding with a high-fat/low-carbohydrate (HF/LC) diet on the onset of type 2 diabetes mellitus in normal rats. Male Wistar Imamichi rats were kept on a Control (carbohydrate 60%, fat 15%) or HF/LC (carbohydrate 10%, fat 65%) diet for 16 months. An intraperitoneal glucose tolerance test was performed once every 2 months."

"Glucose tolerance was impaired two months after the start of HF/LC diet feeding, accompanied by a decrease in the insulinogenic...

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