Diabetes Surgery
Maternal pancreatic islet transplant prevents hypothalamic defect in rat pups
Published in Obesity and Diabetes Week, February 9th, 2004
"Exposure to gestational diabetes (GD) in rats leads to dysplasia of the ventromedial hypothalamic nucleus (VMN), decisively involved into the regulation of body weight and metabolism. Recently, we have shown here that VMN malformation is absent in adult offspring of GD mothers treated by pancreatic islet transplantation during gestation. We therefore now investigated whether VMN malformation and its prevention are already present at the early postnatal end of the critical hypothalamic differentiation period,"...
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