Cardiology
Enhanced permeability explains reduced calcium uptake in cardiac mitochondria
Published in Obesity and Diabetes Week, February 9th, 2004
"Cardiac dysfunction is associated with diabetes. It was previously shown that heart mitochondria from diabetic rats have a reduced calcium accumulation capacity. The objective of this work was to determine whether the reduction in calcium accumulation by cardiac mitochondria from diabetic rats is related to an enhanced susceptibility to induction of the mitochondrial permeability transition," researchers in Portugal report.
"Streptozotocin-induced diabetic rats were used as a model to study the alterations caused by diabetes in the...
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