Insulin
Ser-64 and Ser-111 in PHAS-I dispensable for dissociation from eIF4E
Published in Obesity and Diabetes Week, February 16th, 2004
"Insulin stimulates phosphorylation of multiple sites in the eIF4E-binding protein, PHAS-I, leading to dissociation of the PHAS-I.eIF4E complex and to an increase in cap-dependent translation. The Ser-64 and Ser-111 sites have been proposed to have key roles in controlling the association of PHAS-I and eIF4E. To determine whether the effects of insulin require these sites, we assessed the control of PHAS-I proteins having Ala-64 or Ala-111 mutations," scientists in the United States report.
"The results indicate that phosphorylation of neither site is...
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