Type 2 Diabetes Therapy
Thiazolidinediones reduce free fatty acid levels in type 2 diabetes patients
Published in Obesity and Diabetes Week, February 16th, 2004
According to a study from the United States, "Acute elevation of plasma free fatty acids (FFAs) is necessary for insulin secretion. Sustained elevation, however, leads to apoptosis of pancreatic beta-cells and is a major risk factor for cardiovascular disease and sudden death in patients with insulin resistance or a family history of diabetes mellitus, as well as in individuals with normal glucose tolerance. Data suggest that reduction of FFA plasma levels may reduce the incidence of cardiovascular disease in these at-risk patients."
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