Diabetes Pathogenesis
OX40 ligand dampens anti-islet self-reactivity but promotes diabetes
Published in Obesity and Diabetes Week, February 23rd, 2004
According to a study from the United States, "Costimulatory signals received by diabetogenic T cells during priming by or upon secondary encounter with autoantigen are decisive in determining the outcome of autoimmune attack. The OX40-OX40 ligand (OX40L) costimulatory pathway is known to influence T cell responses, prompting us to examine its role in autoimmune diabetes. A null allele at OX40L completely prevented diabetes development in nonobese diabetic mice and strongly reduced its incidence in a TCR transgenic model (BDC2. 5)."
"However, somewhat paradoxically,...
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