Diabetes Pathogenesis

Expression of adiponectin receptors in pancreatic beta cells reported

Published in Obesity and Diabetes Week, February 23rd, 2004

adiponectin receptors are expressed in pancreatic beta cells.

According to recent research from Belgium, "Pancreatic beta cell dysfunction is an early and crucial pathogenic factor in the development of type 2 diabetes. Free fatty acids (FFA) and adipokines released from adipose tissues lead to both the development of insulin resistance and beta cell dysfunction. Adiponectin is a novel adipokine with antidiabetic properties. Its circulating concentrations are reduced in subjects with increased visceral adiposity, insulin resistance, or type 2 diabetes."

"Very recently, the cloning of two adiponectin receptors AdipoR1 and AdipoR2 was reported," said...

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Source: Obesity and Diabetes Week (2004-02-23)

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