Oncogenesis
Oncogenic ras-p21 proteins induce different isoforms of protein kinase C
Published in Obesity and Diabetes Week, February 23rd, 2004
According to recent research published in the Journal of Protein Chemistry, "We have previously found that the protein kinase C (PKC) inhibitor, CGP 41 251, blocks oncogenic ras-p21 protein- and beta-PKC-induced oocyte maturation, but only weakly inhibits insulin-induced oocyte maturation (which requires activation of wild-type endogenous ras-p21). Because the dose-response curves for inhibition of oncogenic p21- and beta-PKC-induced oocyte maturation by CGP 41 251 superimpose and because the ras-p21-inactivating antibody, Y13-259,...
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