Breast Cancer
Enhanced insulin signaling occurs via Shc in human breast cancer
Published in Obesity and Diabetes Week, February 23rd, 2004
"Insulin is a mild mitogen and has been shown to potentiate mitogenic influence of other growth factors. Because hyperinsulinema and/or overexpression of insulin receptors have been linked to development, progression, and outcome of breast cancer, we attempted to evaluate the mechanism of these associations. We have compared the expression of insulin receptors and the magnitude of insulin signaling in breast tumors and adjacent normal mammary tissue samples obtained from 20 patients," scientists writing in the journal Metabolism - Clinical and Experimental report.
"We observed...
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