Diabetes

Young people prone to type 2 diabetes exhibit alterations in mitochondrial activity

Published in Obesity and Diabetes Week, March 8th, 2004

Researchers at Yale University have found that decreased activity in muscle mitochondria, the powerhouses of the cell, may be a major factor in the development of type 2 diabetes in young, lean offspring of parents with the disease.

They demonstrated a potential mechanism for the accumulation of fat in muscle cells of young, lean, insulin-resistant children of parents with type 2 diabetes by comparing them with insulin-sensitive control subjects matched for age, weight, height and activity.

"There is a strong relationship between lipid content in the muscle and insulin resistance in skeletal muscle," said principal investigator Gerald I. Shulman, MD,...

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Source: Obesity and Diabetes Week (2004-03-08)

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