Diabetes Genomics & Genetics
Potential type 2 diabetes-linked gene characterized in Pima Indians
Published in Obesity and Diabetes Week, March 22nd, 2004
According to recent research published in the journal Molecular Genetics and Metabolism, "Endosulfine alpha (ENSA) is an endogenous ligand of the sulfonylurea receptor 1 (SUR1) that can stimulate insulin secretion by pancreatic beta cells. Originally, an intronless gene coding for this protein was assigned to Chr. 14q, but more recent information available in public databases indicated the position of ENSA on 1q21."
"We show here that the 1q21 locus represents the expressed gene consisting of 6 exons,...
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