Atherosclerosis

Diabetes does not affect atherosclerosis in HDL-deficient mice

Published in Obesity and Diabetes Week, March 22nd, 2004

Diabetes does not affect plasma lipoproteins or atherosclerosis in HDL-deficient mice.

According to a study from the United States, "During the past decade a number of investigators have attempted to develop mouse models of diabetic macrovascular disease. Hyperglycemia might increase vascular damage because it increases oxidant stress. For this reason we studied animals that were deficient in HDL; HDL is widely believed to protect against oxidant stress."

"An inbred line of mice doubly deficient in LDL receptor and apoAI was made diabetic with streptozotocin (STZ); control mice had an average glucose of 7.2±2 mmol/L and STZ-treated mice had an...

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Source: Obesity and Diabetes Week (2004-03-22)

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