Endocrinology
Atypical protein kinase C is target of TC10 signaling pathways
Published in Obesity and Diabetes Week, March 29th, 2004
According to published research from the United States, "Insulin stimulation of adipocytes resulted in the recruitment of atypical PKC (PKCzeta/lambda) to plasma membrane lipid raft microdomains. This redistribution of PKCzeta/lambda was prevented by Clostridium difficile toxin B and by cholesterol depletion, but was unaffected by inhibition of phosphatidylinositol (PI) 3-kinase activity. Expression of the constitutively active GTP-bound form of TO 0 (TC10Q/75L), but not the inactive GDP-bound mutant...
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