Cardiovascular Disease
AT1 receptors linked to insulin resistance-induced vascular dysfunction
Published in Obesity and Diabetes Week, March 29th, 2004
According to recent research from Japan, "Excess production of superoxide anion in response to angiotensin II plays a central role in the transduction of signal molecules and the regulation of vascular tone."
K. Shinozaki and coauthors at the Shiga University of Medical Science "examined the ability of insulin resistance to stimulate superoxide anion production" and "the identity of the oxidases responsible for its production."
"Rats were fed diets containing 60% fructose (fructose-fed rats) or 60% starch (control rats) for...
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