Type 1 Diabetes Risk Factor
Retrovirus K-18 polymorphisms linked to type 1 diabetes
Published in Obesity and Diabetes Week, April 19th, 2004
"Several lines of evidence suggest the involvement of the human endogenous retrovirus (HERV)-K18 in the etiology of type 1 diabetes. HERV-K18 encodes for a T-cell superantigen (SAg). T-cells with T-cell receptor Vbeta7 chains reactive to the SAg and HERV-K18 mRNA were enriched in the tissues at the onset of the disease," investigators in Switzerland and England report.
"HERV-K18 transcription and SAg function in cells capable of efficient presentation are induced by proinflammatory stimuli such as viruses and interferon-alpha and may trigger progression of disease to...
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