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Type 2 Diabetes

Reduced lipid oxidation in type 2 diabetes may be of genetic origin

Published in Obesity and Diabetes Week, April 26th, 2004

Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin.

"Insulin resistance in skeletal muscle in vivo is associated with reduced lipid oxidation and lipid accumulation. It is still uncertain whether changes in lipid metabolism represent an adaptive compensation at the cellular level or a direct expression of a genetic trait. Studies of palmitate metabolism in human myotubes established from control and type 2 diabetic subjects may solve this problem, as genetic defects are preserved and expressed in vitro," scientists in Denmark and Norway report.

"In this study, total uptake of palmitic acid was similar in...

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