Cardiomyopathy

Defective phospholipase C signaling found in diabetic cardiomyopathy

Published in Obesity and Diabetes Week, May 3rd, 2004

Defective phosphatidic acid-phospholipase C signaling is involved in diabetic cardiomyopathy.

"The effects of exogenous phosphatidic acid (PA) on Ca²⁺ transients and contractile activity were studied in cardiomyocytes isolated from chronic streptozotocin-induced diabetic rats. In control cells, 25 micromolar PA induced a significant increase in active cell shortening and Ca²⁺ transients. PA increased IP3 generation in the control cardiomyocytes and its inotropic effects were blocked by a phospholipase C inhibitor," researchers in Canada report.

"In cardiomyocytes from diabetic rats, PA induced a 25% decrease in active cell...

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Source: Obesity and Diabetes Week (2004-05-03)

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