Diabetes Pathogenesis
SREBP-1c expression in liver of diabetic mice is insulin independent
Published in Obesity and Diabetes Week, May 3rd, 2004
"Insulin and glucose together have been previously shown to regulate hepatic sterol regulatory element-binding protein (SREBP)-1c expression. We sought to explore the nutritional regulation of lipogenesis through SREBP-1c induction in a setting where effects of sugars versus insulin could be distinguished. To do so, mice were insulin depleted by streptozotocin (STZ) administration and subjected to a fasting-refeeding protocol with glucose, fructose, or sucrose," scientists in Japan report.
"Unexpectedly,...
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