Obesity Risk Factor
Feeding response to leptin infusion predicts obesity in rats
Published in Obesity and Diabetes Week, May 3rd, 2004
"Obesity is frequently associated with leptin resistance. The present study investigated whether leptin resistance in rats is present before obesity develops, and thus could underlie obesity induced by 16 wk exposure to a liquid, palatable, high-energy diet (HED). Before HED exposure, male Wistar rats (weighing between 330 and 360 g) received intravenous infusions of 20 mcg leptin 2 hours before dark ({{approx}}57 mcg/kg rat)," scientists writing in the Netherlands report.
"Relative to saline infusion, this caused a highly variable effect...
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